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Relationship between consciousness index 2 and remifentanil dose in painless gastroscopy
Release time:
2020-09-16
To investigate the correlation between consciousness index 2 (IOC2) monitoring and remifentanil in painless gastroscopy. Methods Eighty patients underwent painless gastroscopy were randomly divided into group C and R2, R4 and R6 groups, 20 cases in each group. Anesthesia induction: group C received propofol 1.5 ~ 2.5 mg / kg (0.3 mL / s) intravenously, R2, R4, R6 group infusion of propofol and target controlled infusion 2,4,6ng / mL Remifentanil (MINTO model, plasma concentration), stopped infusion of the drug after reaching the target concentration. All groups were maintained with continuous infusion of propofol 4~12 mg/(kg.h), and IOC1 was maintained at The gastroscopy was started at 40 to 60.
When the central rate of operation (HR) and mean arterial pressure (MAP) are higher than 20% of the basal value or when a body reaction occurs, a single dose of propofol 20~40 mg is given, and if necessary, urapidil is given 10-20 mg, HR. When MAP is lower than 20% of the basal value, the infusion is accelerated and the propofol infusion rate is reduced. If necessary, atropine 0.5 mg or ephedrine 5-15 mg is given, and all patients have lower pulse oxygen saturation (spO2). At 95%, the lower joints were lifted. When Sp02 continued to be less than 90% for more than 2 minutes, all operations were stopped, and the mask was inhaled with oxygen and hand-assisted assisted breathing. The preoperative (T1), microscopic examination (T2), endoscopy (T3), and 5 min (T4) IOC1 and IOC2 were recorded in each group, and the lowest IOC2 value and onset time were recorded. IOC2 decreased to the lowest value), perioperative hypotension, hypertension, bradycardia, tachycardia, hypoxemia, physical activity, propofol dosage and recovery time. Results With the increase of remifentanil dose, the amount of propofol in R4 and R6 groups decreased, the recovery time was shortened, the lowest value of IOC2 became smaller, the onset time was shorter (P < 0.05), and the lowest value of IOC2 was compared with Remifen. 297。 The concentration of the negative correlation is a correlation coefficient of a 0. 297. Conclusion IOC2 is negatively correlated with remifentanil. As the dose of remifentanil increases, the onset time is shortened.
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2020-09-16
